![Anti-WT1 antibody [6F-H2] (STJ16100439)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/149156/346775/STJ16100439_1__44042.1681998875.jpg?c=1 "Anti-WT1 antibody [6F-H2] (STJ16100439)")
![Anti-WT1 antibody [6F-H2] (STJ16100439)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/149156/346775/STJ16100439_1__44042.1681998875.jpg?c=1 "Anti-WT1 antibody [6F-H2] (STJ16100439)")
Anti-WT1 antibody [6F-H2] (STJ16100439)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1k
General Information
| Short Description | Mouse monoclonal anti-WT1 for use in IHC-P in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-P |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 6F-H2 |
| Isotype | IgG1k |
| Conjugation | Unconjugated |
| Dilution Range | IHC 1:100 – 1:500 |
| Formulation | Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide |
| Storage Instruction | Store at 2-8°C for up to 1-year, upon receipt. |
Target Information
| Gene Symbol | WT1 |
| Gene ID | 7490 |
| Uniprot ID | WT1_HUMAN |
Additional Info
| Tissue Specificity | Expressed in the kidney and a subset of hematopoietic cells. |
| Function | Transcription factor that plays an important role in cellular development and cell survival. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Isoform 1 has lower affinity for DNA, and can bind RNA. |
| Protein Name | Wilms Tumor ProteinWt33 |
| Database Links | Reactome: R-HSA-9690406Reactome: R-HSA-9831926 |
| Cellular Localisation | NucleusNucleolusCytoplasmIsoforms Lacking The Kts Motif Have A Diffuse Nuclear LocationShuttles Between Nucleus And CytoplasmIsoform 1: Nucleus SpeckleIsoform 4: NucleusNucleoplasm |
| Alternative Antibody Names | Anti-Wilms Tumor Protein antibodyAnti-Wt33 antibodyAnti-WT1 antibody |
Information sourced from Uniprot.org