| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-WHRN (708-907) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
WHRN |
| Gene ID: |
25861 |
| Uniprot ID: |
WHRN_HUMAN |
| Immunogen Region: |
708-907 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 708-907 of human WHRN (NP_056219.3). |
| Immunogen Sequence: |
PSGHPDQTGTNQHFVMVEVH RPDSEPDVNEVRALPQTRTA STLSQLSDSGQTLSEDSGVD AGEAEASAPGRGRQSVSTKS RSSKELPRNERPTDGANKPP GLLEPTSTLVRVKKSAATLG IAIEGGANTRQPLPRIVTIQ RGGSAHNCGQLKVGHVILEV NGLTLRGKEHREAARIIAEA FKTKDRDYIDFLVTEFNVML |
| Function | Involved in hearing and vision as member of the USH2 complex. Necessary for elongation and maintenance of inner and outer hair cell stereocilia in the organ of Corti in the inner ear. Involved in the maintenance of the hair bundle ankle region, which connects stereocilia in cochlear hair cells of the inner ear. In retina photoreceptors, required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport. |
| Protein Name | WhirlinAutosomal Recessive Deafness Type 31 Protein |
| Database Links | Reactome: R-HSA-9662360Reactome: R-HSA-9662361 |
| Cellular Localisation | CytoplasmCell ProjectionStereociliumGrowth ConePhotoreceptor Inner SegmentSynapseDetected At The Level Of Stereocilia In Inner And Outer Hair Cells Of The Cochlea And VestibuleLocalizes To Both Tip And Ankle-Link Stereocilia RegionsColocalizes With The Growing Ends Of Actin FilamentsColocalizes With Mpp1 In The RetinaAt The Outer Limiting Membrane (Olm)Outer Plexifirm Layer (Opl)Basal Bodies And At The Connecting Cilium (Cc)In PhotoreceptorsLocalizes At A Plasma Membrane Microdomain In The Apical Inner Segment That Surrounds The Connecting Cilia Called Periciliary Membrane Complex |
| Alternative Antibody Names | Anti-Whirlin antibodyAnti-Autosomal Recessive Deafness Type 31 Protein antibodyAnti-WHRN antibodyAnti-DFNB31 antibodyAnti-KIAA1526 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
