Anti-WHIP/WRNIP1 antibody (C-Term) (STJ70051)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-WHIP/WRNIP1 (C-Term) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Applications | Pep-ELISA/WB/IHC |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Dog/Cow |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:32000.WB: Approx 90kDa band observed in lysates of cell line Jurkat (calculated MW of 72.1kDa according to NP_064520.2). The observed molecular weight corresponds to earlier findings in literatu |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20ยฐC on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | WRNIP1 |
| Gene ID | 56897 |
| Uniprot ID | WRIP1_HUMAN |
| Accession Number | NP_064520.2; NP_569079.1 |
| Immunogen Region | C-Term |
| Immunogen Sequence | EELRGVDFFKQRRC |
| Specificity | This antibody is expected to recognise isoform 1 (NP_064520.2) and isoform 2 (NP_569079.1). |
Additional Info
| Post Translational Modifications | Sumoylated with SUMO1 and SUMO2/3. |
| Function | Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. In the presence of ATP, stimulation of DNA polymerase delta-mediated DNA synthesis is decreased. Also plays a role in the innate immune defense against viruses. Stabilizes the RIGI dsRNA interaction and promotes RIGI 'Lys-63'-linked polyubiquitination. In turn, RIGI transmits the signal through mitochondrial MAVS. |
| Protein Name | Atpase Wrnip1Werner Helicase-Interacting Protein 1 |
| Cellular Localisation | NucleusCytoplasmColocalizes With Wrn In Granular Structures In The Nucleus |
| Alternative Antibody Names | Anti-Atpase Wrnip1 antibodyAnti-Werner Helicase-Interacting Protein 1 antibodyAnti-WRNIP1 antibodyAnti-WHIP antibody |
Information sourced from Uniprot.org