| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-WFS1 (1-285) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
WFS1 |
| Gene ID: |
7466 |
| Uniprot ID: |
WFS1_HUMAN |
| Immunogen Region: |
1-285 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-285 of human WFS1 (NP_005996.2). |
| Immunogen Sequence: |
MDSNTAPLGPSCPQPPPAPQ PQARSRLNATASLEQERSER PRAPGPQAGPGPGVRDAAAP AEPQAQHTRSRERADGTGPT KGDMEIPFEEVLERAKAGDP KAQTEVGKHYLQLAGDTDEE LNSCTAVDWLVLAAKQGRRE AVKLLRRCLADRRGITSENE REVRQLSSETDLERAVRKAA LVMYWKLNPKKKKQVAVAEL LENVGQVNEHDGGAQPGPVP KSLQKQRRMLERLVSSESK |
| Tissue Specificity | Highly expressed in heart followed by brain, placenta, lung and pancreas. Weakly expressed in liver, kidney and skeletal muscle. Also expressed in islet and beta-cell insulinoma cell line. |
| Function | Participates in the regulation of cellular Ca(2+) homeostasis, at least partly, by modulating the filling state of the endoplasmic reticulum Ca(2+) store. Negatively regulates the ER stress response and positively regulates the stability of V-ATPase subunits ATP6V1A and ATP1B1 by preventing their degradation through an unknown proteasome-independent mechanism. |
| Protein Name | Wolframin |
| Database Links | Reactome: R-HSA-381038Reactome: R-HSA-381426Reactome: R-HSA-8957275 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinCytoplasmic VesicleSecretory VesicleCo-Localizes With Atp6v1a In The Secretory Granules In Neuroblastoma Cell Lines |
| Alternative Antibody Names | Anti-Wolframin antibodyAnti-WFS1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
