Anti-WDR6 antibody (STJA0009080)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human WDR6
General Information
| Short Description | Rabbit polyclonal anti-tRNA-methyltransferase regulator WDR6 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | WDR6 |
| Gene ID | 11180 |
| Uniprot ID | WDR6_HUMAN |
| Immunogen | Synthesized peptide derived from human WDR6 |
| Specificity | This antibody detects endogenous levels of WDR6 at Human, Mouse, Rat |
Additional Info
| Function | Together with methyltransferase FTSJ1, methylates the 2'-O-ribose of nucleotides at position 34 of the tRNA anticodon loop of substrate tRNAs. Required for the correct positioning of the substrate tRNA for methylation. Required to suppress amino acid starvation-induced autophagy. Enhances the STK11/LKB1-induced cell growth suppression activity. |
| Protein Name | Trna34-2'-O-Methyltransferase Regulator Wdr6Wd Repeat-Containing Protein 6 |
| Database Links | Reactome: R-HSA-9013420Reactome: R-HSA-9013424Reactome: R-HSA-9696264Reactome: R-HSA-9696270Reactome: R-HSA-9696273 |
| Cellular Localisation | CytoplasmColocalizes In The Cytoplasm With Stk11/Lkb1 |
| Alternative Antibody Names | Anti-Trna antibodyAnti-34-2'-O-Methyltransferase Regulator Wdr6 antibodyAnti-Wd Repeat-Containing Protein 6 antibodyAnti-WDR6 antibody |
Information sourced from Uniprot.org