Anti-WDR48 antibody (STJA0007467)

SKU:
STJA0007467

Current Stock:
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-WD repeat-containing protein 48 is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: WDR48
Gene ID: 57599
Uniprot ID: WDR48_HUMAN
Specificity: This antibody detects endogenous levels of WDR48 at Human, Mouse
Immunogen: Synthesized peptide derived from human WDR48
Function Regulator of deubiquitinating complexes, which acts as a strong activator of USP1, USP12 and USP46. Enhances the USP1-mediated deubiquitination of FANCD2.USP1 being almost inactive by itself. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. Also activates deubiquitinating activity of complexes containing USP12. In complex with USP12, acts as a potential tumor suppressor by positively regulating PHLPP1 stability. Docks at the distal end of the USP12 fingers domain and induces a cascade of structural changes leading to the activation of the enzyme. Together with RAD51AP1, promotes DNA repair by stimulating RAD51-mediated homologous recombination. Binds single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). DNA-binding is required both for USP1-mediated deubiquitination of FANCD2 and stimulation of RAD51-mediated homologous recombination: both WDR48/UAF1 and RAD51AP1 have coordinated role in DNA-binding during these processes. Together with ATAD5 and by regulating USP1 activity, has a role in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA. Together with ATAD5, has a role in recruiting RAD51 to stalled forks during replication stress. (Microbial infection) In case of infection by Herpesvirus saimiri, may play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes. Induces lysosomal vesicle formation via interaction with Herpesvirus saimiri tyrosine kinase-interacting protein (TIP). Subsequently, TIP recruits tyrosine-protein kinase LCK, resulting in down-regulation of T-cell antigen receptor TCR. May play a role in generation of enlarged endosomal vesicles via interaction with TIP. In case of infection by papillomavirus HPV11, promotes the maintenance of the viral genome via its interaction with HPV11 helicase E1.
Protein Name Wd Repeat-Containing Protein 48
Usp1-Associated Factor 1
Wd Repeat Endosomal Protein
P80
Database Links Reactome: R-HSA-110314
Reactome: R-HSA-5689880
Reactome: R-HSA-6783310
Reactome: R-HSA-9673766
Cellular Localisation Nucleus
Cytoplasm
Lysosome
Late Endosome
Mainly In Cytoplasmic Compartments
In Case Of Infection By Papillomavirus Hpv11
Translocates To The Nucleus Via Its Interaction With Papillomavirus Hpv11
Alternative Antibody Names Anti-Wd Repeat-Containing Protein 48 antibody
Anti-Usp1-Associated Factor 1 antibody
Anti-Wd Repeat Endosomal Protein antibody
Anti-P80 antibody
Anti-WDR48 antibody
Anti-KIAA1449 antibody
Anti-UAF1 antibody

Information sourced from Uniprot.org

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