Anti-WDR46 antibody (421-610) (STJ11103980)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal Wd Repeat-Containing Protein 46 (421-610) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | WDR46 |
| Gene ID | 9277 |
| Uniprot ID | WDR46_HUMAN |
| Immunogen Region | 421-610 |
| Immunogen Sequence | DVVNIWAGQGKASPPSLEQP YLTHRLSGPVHGLQFCPFED VLGVGHTGGITSMLVPGAGE PNFDGLESNPYRSRKQRQEW EVKALLEKVPAELICLDPRA LAEVDVISLEQGKKEQIERL GYDPQAKAPFQPKPKQKGRS STASLVKRKRKVMDEEHRDK VRQSLQQQHHKEAKAKPTGA RPSALDRFVR |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 421-610 of human WDR46 (NP_005443.3). |
Additional Info
| Function | Scaffold component of the nucleolar structure. Required for localization of DDX21 and NCL to the granular compartment of the nucleolus. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. |
| Protein Name | Wd Repeat-Containing Protein 46Wd Repeat-Containing Protein Bing4 |
| Database Links | Reactome: R-HSA-6790901Reactome: R-HSA-6791226 |
| Cellular Localisation | NucleusNucleolus |
| Alternative Antibody Names | Anti-Wd Repeat-Containing Protein 46 antibodyAnti-Wd Repeat-Containing Protein Bing4 antibodyAnti-WDR46 antibodyAnti-BING4 antibodyAnti-C6orf11 antibodyAnti-FP221 antibody |
Information sourced from Uniprot.org