| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-WDR11 (975-1224) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
WDR11 |
| Gene ID: |
55717 |
| Uniprot ID: |
WDR11_HUMAN |
| Immunogen Region: |
975-1224 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 975-1224 of human WDR11 (NP_060587.8). |
| Immunogen Sequence: |
YFQKFQLERVNLQEVKRSTY DHTRKCTDQLLLLGQTDRAV QLLLETSADNQHYYCDSLKA CLVTTVTSSGPSQSTIKLVA TNMIANGKLAEGVQLLCLID KAADACRYLQTYGEWNRAAW LAKVRLNPEECADVLRRWVD HLCSPQVNQKSKALLVLLSL GCFFSVAETLHSMRYFDRAA LFVEACLKYGAFEVTEDTEK LITAIYADYARSLKNLGFKQ GAVLFASKAGAAGKDLLNE |
| Tissue Specificity | Ubiquitous. |
| Function | Involved in the Hedgehog (Hh) signaling pathway, is essential for normal ciliogenesis. Regulates the proteolytic processing of GLI3 and cooperates with the transcription factor EMX1 in the induction of downstream Hh pathway gene expression and gonadotropin-releasing hormone production. WDR11 complex facilitates the tethering of Adaptor protein-1 complex (AP-1)-derived vesicles. WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1. |
| Protein Name | Wd Repeat-Containing Protein 11Bromodomain And Wd Repeat-Containing Protein 2Wd Repeat-Containing Protein 15 |
| Database Links | Reactome: R-HSA-9013407 |
| Cellular Localisation | CytoplasmCytoskeletonCilium Basal BodyNucleusCilium AxonemeCytoplasmic VesicleGolgi ApparatusTrans-Golgi NetworkShuttles From The Cilium To The Nucleus In Response To Hh SignalingMight Be Shuttling Between The Nucleus And The Cytoplasm |
| Alternative Antibody Names | Anti-Wd Repeat-Containing Protein 11 antibodyAnti-Bromodomain And Wd Repeat-Containing Protein 2 antibodyAnti-Wd Repeat-Containing Protein 15 antibodyAnti-WDR11 antibodyAnti-BRWD2 antibodyAnti-KIAA1351 antibodyAnti-WDR15 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
