Anti-WDR1 antibody (325-339 aa) [R01-6D6] (STJA0012136)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide of human WDR1
General Information
| Short Description | Rabbit monoclonal anti-WDR1 (325-339 aa) for use in WB, IHC-F, IHC-P, ICC and IF in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-F/IHC-P/ICC/IF |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R01-6D6 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100IF 1:50-1:200 |
| Formulation | 50mM Tris-Glycine (pH7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | WDR1 |
| Gene ID | 9948 |
| Uniprot ID | WDR1_HUMAN |
| Immunogen | A synthetic peptide of human WDR1 |
| Immunogen Region | 325-339 aa |
Additional Info
| Tissue Specificity | Expressed in peripheral blood mononuclear cells (at protein level). |
| Function | Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins. Enhances cofilin-mediated actin severing. Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions. Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance. Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP.the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension. Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt. |
| Protein Name | Wd Repeat-Containing Protein 1Actin-Interacting Protein 1Aip1Nori-1 |
| Database Links | Reactome: R-HSA-114608 |
| Cellular Localisation | CytoplasmCytoskeletonCell ProjectionPodosomeCell Junction |
| Alternative Antibody Names | Anti-Wd Repeat-Containing Protein 1 antibodyAnti-Actin-Interacting Protein 1 antibodyAnti-Aip1 antibodyAnti-Nori-1 antibodyAnti-WDR1 antibody |
Information sourced from Uniprot.org