| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-WDR1 (300-500) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
WDR1 |
| Gene ID: |
9948 |
| Uniprot ID: |
WDR1_HUMAN |
| Immunogen Region: |
300-500 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 300-500 of human WDR1 (NP_059830.1). |
| Immunogen Sequence: |
YINYLDRNNPSKPLHVIKGH SKSIQCLTVHKNGGKSYIYS GSHDGHINYWDSETGENDSF AGKGHTNQVSRMTVDESGQL ISCSMDDTVRYTSLMLRDYS GQGVVKLDVQPKCVAVGPGG YAVVVCIGQIVLLKDQRKCF SIDNPGYEPEVVAVHPGGDT VAIGGVDGNVRLYSILGTTL KDEGKLLEAKGPVTDVAYSH D |
| Tissue Specificity | Expressed in peripheral blood mononuclear cells (at protein level). |
| Function | Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins. Enhances cofilin-mediated actin severing. Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions. Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance. Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP.the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension. Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt. |
| Protein Name | Wd Repeat-Containing Protein 1Actin-Interacting Protein 1Aip1Nori-1 |
| Database Links | Reactome: R-HSA-114608 |
| Cellular Localisation | CytoplasmCytoskeletonCell ProjectionPodosomeCell Junction |
| Alternative Antibody Names | Anti-Wd Repeat-Containing Protein 1 antibodyAnti-Actin-Interacting Protein 1 antibodyAnti-Aip1 antibodyAnti-Nori-1 antibodyAnti-WDR1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
