| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-WARS (1-270) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
WARS1 |
| Gene ID: |
7453 |
| Uniprot ID: |
SYWC_HUMAN |
| Immunogen Region: |
1-270 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human Tryptophanyl-tRNA synthetase 1 (NP_776049.1). |
| Immunogen Sequence: |
MPNSEPASLLELFNSIATQG ELVRSLKAGNASKDEIDSAV KMLVSLKMSYKAAAGEDYKA DCPPGNPAPTSNHGPDATEA EEDFVDPWTVQTSSAKGIDY DKLIVRFGSSKIDKELINRI ERATGQRPHHFLRRGIFFSH RDMNQVLDAYENKKPFYLYT GRGPSSEAMHVGHLIPFIFT KWLQDVFNVPLVIQMTDDEK YLWKDLTLDQAYSYAVENAK DIIACGFDINKTFIFSDLD |
| Post Translational Modifications | Proteolytic cleavage generates 2 forms.T1-TrpRS and T2-TrpRS. |
| Function | Isoform 1, isoform 2 and T1-TrpRS have aminoacylation activity while T2-TrpRS lacks it. Isoform 2, T1-TrpRS and T2-TrpRS possess angiostatic activity whereas isoform 1 lacks it. T2-TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression. |
| Protein Name | Tryptophan--Trna Ligase - CytoplasmicInterferon-Induced Protein 53Ifp53Tryptophanyl-Trna SynthetaseTrprsHwrs Cleaved Into - T1-Trprs - T2-Trprs |
| Database Links | Reactome: R-HSA-379716 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Tryptophan--Trna Ligase - Cytoplasmic antibodyAnti-Interferon-Induced Protein 53 antibodyAnti-Ifp53 antibodyAnti-Tryptophanyl-Trna Synthetase antibodyAnti-Trprs antibodyAnti-Hwrs Cleaved Into - T1-Trprs - T2-Trprs antibodyAnti-WARS1 antibodyAnti-IFI53 antibodyAnti-WARS antibodyAnti-WRS antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
