Anti-WAPL antibody [R05-3V9] (STJA0037129)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human WAPL
General Information
| Short Description | Rabbit monoclonal anti-WAPL for use in WB, ICC, IF and IP in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ICC/IF/IP |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R05-3V9 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IF 1:50-1:200IP 1:50 |
| Formulation | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | WAPL |
| Gene ID | 23063 |
| Uniprot ID | WAPL_HUMAN |
| Immunogen | A synthesized peptide derived from human WAPL |
Additional Info
| Tissue Specificity | Isoform 1 is highly expressed in uterine cervix tumor. Isoform 2 is widely expressed with a high level in skeletal muscle and heart. |
| Post Translational Modifications | Deubiquitinated by USP37.leading to stabilization. |
| Function | Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. |
| Protein Name | Wings Apart-Like Protein HomologFriend Of Ebna2 ProteinWapl Cohesin Release Factor |
| Database Links | Reactome: R-HSA-2467813Reactome: R-HSA-2468052Reactome: R-HSA-2470946Reactome: R-HSA-2500257 |
| Cellular Localisation | Isoform 2: NucleusNucleusChromosomeCytoplasmAssociates With Chromatin Through The Cohesin Complex During InterphaseReleased In The Cytoplasm From Nuclear Envelope Breakdown Until AnaphaseIt Reaccumulates In Nucleus At Telophase |
| Alternative Antibody Names | Anti-Wings Apart-Like Protein Homolog antibodyAnti-Friend Of Ebna2 Protein antibodyAnti-Wapl Cohesin Release Factor antibodyAnti-WAPL antibodyAnti-FOE antibodyAnti-KIAA0261 antibodyAnti-WAPAL antibody |
Information sourced from Uniprot.org