Host: | Rabbit |
Applications: | WB/IF |
Reactivity: | Human/Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit monoclonal antibody anti-WAPL (1-100) is suitable for use in Western Blot and Immunofluorescence research applications. |
Clonality: | Monoclonal |
Clone ID: | S0MR |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
Purification: | Affinity purification |
Dilution Range: | WB 1:500-1:1000 IF/ICC 1:50-1:200 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | WAPL |
Gene ID: | 23063 |
Uniprot ID: | WAPL_HUMAN |
Immunogen Region: | 1-100 |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human WAPL (Q7Z5K2). |
Immunogen Sequence: | MTSRFGKTYSRKGGNGSSKF DEVFSNKRTTLSTKWGETTF MAKLGQKRPNFKPDIQEIPK KPKVEEESTGDPFGFDSDDE SLPVSSKNLAQVKCSSYSES |
Tissue Specificity | Isoform 1 is highly expressed in uterine cervix tumor. Isoform 2 is widely expressed with a high level in skeletal muscle and heart. |
Post Translational Modifications | Deubiquitinated by USP37.leading to stabilization. |
Function | Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. |
Protein Name | Wings Apart-Like Protein Homolog Friend Of Ebna2 Protein Wapl Cohesin Release Factor |
Database Links | Reactome: R-HSA-2467813 Reactome: R-HSA-2468052 Reactome: R-HSA-2470946 Reactome: R-HSA-2500257 |
Cellular Localisation | Isoform 2: Nucleus Nucleus Chromosome Cytoplasm Associates With Chromatin Through The Cohesin Complex During Interphase Released In The Cytoplasm From Nuclear Envelope Breakdown Until Anaphase It Reaccumulates In Nucleus At Telophase |
Alternative Antibody Names | Anti-Wings Apart-Like Protein Homolog antibody Anti-Friend Of Ebna2 Protein antibody Anti-Wapl Cohesin Release Factor antibody Anti-WAPL antibody Anti-FOE antibody Anti-KIAA0261 antibody Anti-WAPAL antibody |
Information sourced from Uniprot.org