Anti-VPS37B antibody (60-170) (STJ119806)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal VPS37B (60-170) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | VPS37B |
| Gene ID | 79720 |
| Uniprot ID | VP37B_HUMAN |
| Immunogen Region | 60-170 |
| Immunogen Sequence | LLYQPQLDTLKARLTQKYQE LQVLFEAYQIKKTKLDRQSS SASLETLLALLQAEGAKIEE DTENMAEKFLDGELPLDSFI DVYQSKRKLAHMRRVKIEKL QEMVLKGQRLP |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 60-170 of human VPS37B (NP_078943.1). |
Additional Info
| Tissue Specificity | Widely expressed. Expressed in macrophages and lymphocytes. |
| Function | Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation. |
| Protein Name | Vacuolar Protein Sorting-Associated Protein 37bHvps37bEscrt-I Complex Subunit Vps37b |
| Database Links | Reactome: R-HSA-162588Reactome: R-HSA-174490Reactome: R-HSA-917729Reactome: R-HSA-9610379Reactome: R-HSA-9615710 |
| Cellular Localisation | Late Endosome MembranePeripheral Membrane ProteinRecruited To The Endosomal Membrane In A Vps4a-Dependent Fashion |
| Alternative Antibody Names | Anti-Vacuolar Protein Sorting-Associated Protein 37b antibodyAnti-Hvps37b antibodyAnti-Escrt-I Complex Subunit Vps37b antibodyAnti-VPS37B antibody |
Information sourced from Uniprot.org