| Host: |
Rabbit |
| Applications: |
ELISA/IP/WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-VPS36 (250-310) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Purification: |
Affinity Purified |
| Concentration: |
0.5-1.5 µg/µl |
| Dilution Range: |
WB: 1:2, 500-1:5, 000ELISA: 1:50, 000IP: 1:200 |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
VPS36 |
| Gene ID: |
51028 |
| Uniprot ID: |
VPS36_HUMAN |
| Immunogen Region: |
250-310 |
| Immunogen: |
Synthetic peptide taken within amino acid region 250-310 on human Vacuolar Protein-Sorting-associated protein 36 protein. |
| Function | Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3. |
| Protein Name | Vacuolar Protein-Sorting-Associated Protein 36Ell-Associated Protein Of 45 KdaEscrt-Ii Complex Subunit Vps36 |
| Database Links | Reactome: R-HSA-917729Reactome: R-HSA-9610379 |
| Cellular Localisation | CytoplasmEndosomeLate EndosomeMembraneNucleusColocalizes With Ubiquitinated Proteins On Late EndosomesRecruited To The Endosome Membrane To Participate In Vesicle Formation |
| Alternative Antibody Names | Anti-Vacuolar Protein-Sorting-Associated Protein 36 antibodyAnti-Ell-Associated Protein Of 45 Kda antibodyAnti-Escrt-Ii Complex Subunit Vps36 antibodyAnti-VPS36 antibodyAnti-C13orf9 antibodyAnti-EAP45 antibodyAnti-CGI-145 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
