Anti-VPS25 antibody (STJA0007101)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human VPS25
General Information
| Short Description | Rabbit polyclonal anti-Vacuolar protein-sorting-associated protein 25 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | VPS25 |
| Gene ID | 84313 |
| Uniprot ID | VPS25_HUMAN |
| Immunogen | Synthesized peptide derived from human VPS25 |
| Specificity | This antibody detects endogenous levels of VPS25 at Human, Mouse, Rat |
Additional Info
| Function | Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. The ESCRT-II complex may be involved in facilitating the budding of certain RNA viruses. |
| Protein Name | Vacuolar Protein-Sorting-Associated Protein 25Hvps25Dermal Papilla-Derived Protein 9Ell-Associated Protein Of 20 KdaEscrt-Ii Complex Subunit Vps25 |
| Database Links | Reactome: R-HSA-917729Reactome: R-HSA-9610379 |
| Cellular Localisation | CytoplasmEndosome MembraneNucleusNucleoplasmDistributes Diffusely Throughout The Cytoplasm And NucleoplasmBut Exhibits A Punctate Distribution On Coexpression With Chmp6 |
| Alternative Antibody Names | Anti-Vacuolar Protein-Sorting-Associated Protein 25 antibodyAnti-Hvps25 antibodyAnti-Dermal Papilla-Derived Protein 9 antibodyAnti-Ell-Associated Protein Of 20 Kda antibodyAnti-Escrt-Ii Complex Subunit Vps25 antibodyAnti-VPS25 antibodyAnti-DERP9 antibodyAnti-EAP20 antibody |
Information sourced from Uniprot.org