Anti-VMAT2 antibody (STJ16102790)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
ImmunogenSynthetic peptide (CQSYPIGDDEESESD-OH) from the C-terminus of rat VMAT2 conjugated to BSA
General Information
| Short Description | Rabbit polyclonal anti-VMAT2 for use in IHC-F in Dog, Guinea Pig, Hamster, Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-F |
| Host | Rabbit |
| Reactivity | Dog/Guinea Pig/Hamster/Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Dilution Range | IHCF 1:800-1:1, 200 |
| Formulation | Lyophilized; reconstitute in 100 ยตl dist. water |
| Storage Instruction | Store at 2-8ยฐC for up to 1-year, upon receipt. |
Target Information
| Gene Symbol | SLC18A2 |
| Gene ID | 6571 |
| Uniprot ID | VMAT2_HUMAN |
| Immunogen | Synthetic peptide (CQSYPIGDDEESESD-OH) from the C-terminus of rat VMAT2 conjugated to BSA |
Additional Info
| Function | Electrogenic antiporter that exchanges one cationic monoamine with two intravesicular protons across the membrane of secretory and synaptic vesicles. Uses the electrochemical proton gradient established by the V-type proton-pump ATPase to accumulate high concentrations of monoamines inside the vesicles prior to their release via exocytosis. Transports a variety of catecholamines such as dopamine, adrenaline and noradrenaline, histamine, and indolamines such as serotonin. Regulates the transvesicular monoaminergic gradient that determines the quantal size. Mediates somatodendritic dopamine release in hippocampal neurons, likely as part of a regulated secretory pathway that integrates retrograde synaptic signals. Acts as a primary transporter for striatal dopamine loading ensuring impulse-dependent release of dopamine at the synaptic cleft. Responsible for histamine and serotonin storage and subsequent corelease from mast cell granules. |
| Protein Name | Synaptic Vesicular Amine TransporterSolute Carrier Family 18 Member 2Vesicular Amine Transporter 2Vat2Vesicular Monoamine Transporter 2 |
| Database Links | Reactome: R-HSA-181429Reactome: R-HSA-181430Reactome: R-HSA-212676Reactome: R-HSA-442660 |
| Cellular Localisation | Cytoplasmic VesicleSecretory VesicleSynaptic Vesicle MembraneMulti-Pass Membrane ProteinSecretory Vesicle MembraneCell ProjectionAxonDendriteSorted To Large Dense Core Granules In Neuroendocrine CellsPresumably At The Level Of The Trans-Golgi NetworkIn Neurons It Is Predominantly Detected In Somatodendritic Tubulovesicular MembranesA Distinct Population Of Secretory Vesicles That Undergo Calcium-Dependent Exocytosis In Axons And Dendrites Upon DepolarizationLocalized At Synaptic Vesicles In Axons |
| Alternative Antibody Names | Anti-Synaptic Vesicular Amine Transporter antibodyAnti-Solute Carrier Family 18 Member 2 antibodyAnti-Vesicular Amine Transporter 2 antibodyAnti-Vat2 antibodyAnti-Vesicular Monoamine Transporter 2 antibodyAnti-SLC18A2 antibodyAnti-SVMT antibodyAnti-VMAT2 antibody |
Information sourced from Uniprot.org