Anti-VEGFC antibody (112-227 aa) [S5035RM] (STJ11105035)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal Vascular Endothelial Growth Factor C (112-227 aa) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S5035RM |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | VEGFC |
| Gene ID | 7424 |
| Uniprot ID | VEGFC_HUMAN |
| Immunogen Region | 112-227 aa |
| Immunogen Sequence | AHYNTEILKSIDNEWRKTQC MPREVCIDVGKEFGVATNTF FKPPCVSVYRCGGCCNSEGL QCMNTSTSYLSKTLFEITVP LSQGPKPVTISFANHTSCRC MSKLDVYRQVHSIIRR |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 112-227 of human VEGFC. (NP_005420.1). |
Additional Info
| Tissue Specificity | Expressed in the spleen. Expressed in the lymph node, thymus, appendix and bone marrow. Expressed in the heart, placenta, skeletal muscle, ovary and small intestine. Expressed in the prostate, testis and colon. |
| Post Translational Modifications | Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3, but only the fully processed form could activate VEGFR-2. VEGF-C first form an antiparallel homodimer linked by disulfide bonds. Before secretion, a cleavage occurs between Arg-227 and Ser-228 producing a heterotetramer. The next extracellular step of the processing removes the N-terminal propeptide. Finally the mature VEGF-C is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions. |
| Function | Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates KDR/VEGFR2 and FLT4/VEGFR3 receptors. |
| Protein Name | Vascular Endothelial Growth Factor CVegf-CFlt4 LigandFlt4-LVascular Endothelial Growth Factor-Related ProteinVrp |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-194313Reactome: R-HSA-195399 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Vascular Endothelial Growth Factor C antibodyAnti-Vegf-C antibodyAnti-Flt4 Ligand antibodyAnti-Flt4-L antibodyAnti-Vascular Endothelial Growth Factor-Related Protein antibodyAnti-Vrp antibodyAnti-VEGFC antibody |
Information sourced from Uniprot.org