Anti-VEGF antibody [VEGF-21] (STJ16101009)

Clonality:	Monoclonal
Clone ID:	VEGF-21
Conjugation:	Unconjugated
Isotype:	IgG1k
Formulation:	PBS with 0.02% Sodium Azide.
Purification:	Affinity purified from tissue culture.
Concentration:	Can be provided as 100 µg/mL, 500 µg/mL or 1mg/mL.
Dilution Range:	Flow Cytometry (1-2 µg/million cells in 0, 1 ml). Immunofluorescence (1-2 µg/ml). Immunohistology (2-4 µg/ml for 30 min at RT; staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed
Storage Instruction:	Store for up to 1 year at 2-8°C upon receipt.

Gene Symbol:	VEGFC
Gene ID:	7424
Uniprot ID:	VEGFC_HUMAN
Immunogen:	A BALB/c mouse was immunized with human VEGF189 recombinant protein.

Tissue Specificity	Spleen, lymph node, thymus, appendix, bone marrow, heart, placenta, ovary, skeletal muscle, prostate, testis, colon and small intestine and fetal liver, lung and kidney, but not in peripheral blood lymphocyte.
Post Translational Modifications	Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3, but only the fully processed form could activate VEGFR-2. VEGF-C first form an antiparallel homodimer linked by disulfide bonds. Before secretion, a cleavage occurs between Arg-227 and Ser-228 producing a heterotetramer. The next extracellular step of the processing removes the N-terminal propeptide. Finally the mature VEGF-C is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions.
Function	Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates KDR/VEGFR2 and FLT4/VEGFR3 receptors.
Protein Name	Vascular Endothelial Growth Factor C Vegf-C Flt4 Ligand Flt4-L Vascular Endothelial Growth Factor-Related Protein Vrp
Database Links	Reactome: R-HSA-114608 Reactome: R-HSA-194313 Reactome: R-HSA-195399
Cellular Localisation	Secreted
Alternative Antibody Names	Anti-Vascular Endothelial Growth Factor C antibody Anti-Vegf-C antibody Anti-Flt4 Ligand antibody Anti-Flt4-L antibody Anti-Vascular Endothelial Growth Factor-Related Protein antibody Anti-Vrp antibody Anti-VEGFC antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance