Anti-VDR antibody (Internal) (STJ70723)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-VDR (Internal) is suitable for use in ELISA, Western Blot and Flow Cytometry research applications. |
| Applications | Pep-ELISA/WB/FC |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Dog |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:16000.WB: Approx 55kDa band observed in Human Placenta and Duodenum lysates and approx. 55-60kDa in lysates of cell line U937 (calculated MW of 55.2kDa according to NP_001351014.1). Recommended |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | VDR |
| Gene ID | 7421 |
| Uniprot ID | VDR_HUMAN |
| Accession Number | NP_000367.1; NP_001017535.1 |
| Immunogen Region | Internal |
| Immunogen Sequence | CGNQDYKYRVSD |
| Specificity | Both transcript variants (NP_000367.1; NP_001017535.1) encode the same protein. |
Additional Info
| Function | Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells. Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR. The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes. Plays a central role in calcium homeostasis. Also functions as a receptor for the secondary bile acid lithocholic acid (LCA) and its metabolites. |
| Protein Name | Vitamin D3 ReceptorVdr1 -25-Dihydroxyvitamin D3 ReceptorNuclear Receptor Subfamily 1 Group I Member 1 |
| Database Links | Reactome: R-HSA-196791Reactome: R-HSA-383280Reactome: R-HSA-4090294 |
| Cellular Localisation | NucleusCytoplasmLocalizes Mainly To The NucleusTranslocated Into The Nucleus Via Both Ligand-Dependent And Ligand-Independent PathwaysLigand-Independent Nuclear Translocation Is Mediated By Ipo4 |
| Alternative Antibody Names | Anti-Vitamin D3 Receptor antibodyAnti-Vdr antibodyAnti-1 -25-Dihydroxyvitamin D3 Receptor antibodyAnti-Nuclear Receptor Subfamily 1 Group I Member 1 antibodyAnti-VDR antibodyAnti-NR1I1 antibody |
Information sourced from Uniprot.org