Host: | Rabbit |
Applications: | WB |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-Voltage-Dependent Anion-Selective Channel Protein 2 (1-309) is suitable for use in Western Blot research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.01% thimerosal, 50% Glycerol, pH7.3. |
Purification: | Affinity purification |
Dilution Range: | WB 1:500-1:2000 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | VDAC2 |
Gene ID: | 7417 |
Uniprot ID: | VDAC2_HUMAN |
Immunogen Region: | 1-309 |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-309 of human VDAC2 (NP_001171712.1). |
Immunogen Sequence: | MSWCNELRLPALKQHSIGRG LESHITMCIPPSYADLGKAA RDIFNKGFGFGLVKLDVKTK SCSGVEFSTSGSSNTDTGKV TGTLETKYKWCEYGLTFTEK WNTDNTLGTEIAIEDQICQG LKLTFDTTFSPNTGKKSGKI KSSYKRECINLGCDVDFDFA GPAIHGSAVFGYEGWLAGYQ MTFDSAKSKLTRNNFAVGYR TGDFQLHTNVNDGTEFGGSI YQKVCEDLDTSVNLAWTSG |
Tissue Specificity | Expressed in erythrocytes (at protein level). Expressed in all tissues examined. |
Post Translational Modifications | Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30. |
Function | Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. Binds various lipids, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterol cholesterol. Binding of ceramide promotes the mitochondrial outer membrane permeabilization (MOMP) apoptotic pathway. |
Protein Name | Voltage-Dependent Anion-Selective Channel Protein 2 Vdac-2 Hvdac2 Outer Mitochondrial Membrane Protein Porin 2 |
Database Links | Reactome: R-HSA-5689880 Reactome: R-HSA-8949215 |
Cellular Localisation | Mitochondrion Outer Membrane Membrane May Localize To Non-Mitochondrial Membranes |
Alternative Antibody Names | Anti-Voltage-Dependent Anion-Selective Channel Protein 2 antibody Anti-Vdac-2 antibody Anti-Hvdac2 antibody Anti-Outer Mitochondrial Membrane Protein Porin 2 antibody Anti-VDAC2 antibody |
Information sourced from Uniprot.org