Anti-Vav2 antibody (STJA0041438)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenVav2 synthetic peptide (coupled to KLH) corresponding to amino acid residues surrounding Tyr-172 in mouse Vav2. This sequence has high homology with similar regions in rat and human Vav2, and has significant homology to the conserved site in Vav1 and
General Information
| Short Description | Rabbit polyclonal anti-Vav2 for use in ELISA, WB, ICC and IP in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/WB/ICC/IP |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Antigen Affinity Purified |
| Dilution Range | WB 1:1000ICC 1:50IP 1:100 |
| Formulation | PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol |
| Storage Instruction | Storage at-20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at-20°C. |
Target Information
| Gene Symbol | Vav2 |
| Gene ID | 22325 |
| Uniprot ID | VAV2_MOUSE |
| Immunogen | Vav2 synthetic peptide (coupled to KLH) corresponding to amino acid residues surrounding Tyr-172 in mouse Vav2. This sequence has high homology with similar regions in rat and human Vav2, and has significant homology to the conserved site in Vav1 and |
| Immunogen Sequence | Mouse |
| Specificity | The antibody detects a 100 kDa* band corresponding to Vav2 on SDS-PAGE immunoblots of human A431 cells and detects several Vav isoforms in Jurkat cells. |
Additional Info
| Post Translational Modifications | Phosphorylated on tyrosine residues in response to FGR activation. |
| Function | Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. |
| Protein Name | Guanine Nucleotide Exchange Factor Vav2Vav-2 |
| Database Links | Reactome: R-MMU-114604Reactome: -MMU-193648Reactome: -MMU-2029482Reactome: -MMU-2424491Reactome: -MMU-2871796Reactome: -MMU-2871809Reactome: -MMU-3928665Reactome: -MMU-416482Reactome: -MMU-4420097Reactome: -MMU-445144Reactome: -MMU-5218920Reactome: -MMU-8980692Reactome: -MMU-9013026Reactome: -MMU-9013106Reactome: -MMU-9013148Reactome: -MMU-9013149Reactome: -MMU-9013404Reactome: -MMU-9013408Reactome: -MMU-9013423Reactome: -MMU-9748787 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Guanine Nucleotide Exchange Factor Vav2 antibodyAnti-Vav-2 antibodyAnti-Vav2 antibody |
Information sourced from Uniprot.org