Anti-VAV1 antibody (374-590) (STJ117302)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal VAV1 (374-590) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | VAV1 |
| Gene ID | 7409 |
| Uniprot ID | VAV_HUMAN |
| Immunogen Region | 374-590 |
| Immunogen Sequence | KRDNETLRQITNFQLSIENL DQSLAHYGRPKIDGELKITS VERRSKMDRYAFLLDKALLI CKRRGDSYDLKDFVNLHSFQ VRDDSSGDRDNKKWSHMFLL IEDQGAQGYELFFKTRELKK KWMEQFEMAISNIYPENATA NGHDFQMFSFEETTSCKACQ MLLRGTFYQGYRCHRCRASA HKECLGRVPPCGRHGQDFPG TMKKDKLHRRAQDKKRN |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 374-590 of human VAV1 (NP_005419.2). |
Additional Info
| Tissue Specificity | Widely expressed in hematopoietic cells but not in other cell types. |
| Post Translational Modifications | Phosphorylated on tyrosine residues by HCK in response to IFNG and bacterial lipopolysaccharide (LPS). Phosphorylated by FYN. |
| Function | Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation. |
| Protein Name | Proto-Oncogene Vav |
| Database Links | Reactome: R-HSA-114604Reactome: R-HSA-1257604Reactome: R-HSA-1433557Reactome: R-HSA-193648Reactome: R-HSA-2029482Reactome: R-HSA-2219530Reactome: R-HSA-2871796Reactome: R-HSA-2871809Reactome: R-HSA-389359Reactome: R-HSA-416482Reactome: R-HSA-4420097Reactome: R-HSA-512988Reactome: R-HSA-5218920Reactome: R-HSA-6811558Reactome: R-HSA-8980692Reactome: R-HSA-9013149Reactome: R-HSA-9013404Reactome: R-HSA-9013408Reactome: R-HSA-9027284Reactome: R-HSA-912631Reactome: R-HSA-9664422Reactome: R-HSA-9679191Reactome: R-HSA-9748787Reactome: R-HSA-983695 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Proto-Oncogene Vav antibodyAnti-VAV1 antibodyAnti-VAV antibody |
Information sourced from Uniprot.org