| Function | Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function. Critical for spindle function and accurate chromosome segregation during mitosis since microtubule detyronisation regulates mitotic spindle length and postioning. Acts as an activator of angiogenesis: expressed in infiltrating mononuclear cells in the sprouting front to promote angiogenesis. Plays a role in axon formation. |
| Protein Name | Tubulinyl-Tyr Carboxypeptidase 2Vasohibin-2Vasohibin-Like Protein |
| Database Links | Reactome: R-HSA-8955332 |
| Cellular Localisation | CytoplasmSecretedCytoskeletonMainly Localizes In The CytoplasmSome Fraction Is Secreted Via A Non-Canonical Secretion SystemInteraction With Svbp Promotes SecretionAssociates With Microtubules |
| Alternative Antibody Names | Anti-Tubulinyl-Tyr Carboxypeptidase 2 antibodyAnti-Vasohibin-2 antibodyAnti-Vasohibin-Like Protein antibodyAnti-VASH2 antibodyAnti-VASHL antibody |
Information sourced from Uniprot.org
