Anti-VASH2 antibody [16G2] (STJA0032583)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2b
ImmunogenHSPTQVRSRGKSLSPRRRQASPPRRLGRREKSPALPEKKVADLSTLNEVG peptide conjugated to carrier protein
General Information
| Short Description | Mouse monoclonal anti-VASH2 for use in WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 16G2 |
| Isotype | IgG2b |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000 |
| Formulation | Liquid in PBS containing 0.09% sodium azide as a preservative. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | VASH2 |
| Gene ID | 79805 |
| Uniprot ID | VASH2_HUMAN |
| Immunogen | HSPTQVRSRGKSLSPRRRQASPPRRLGRREKSPALPEKKVADLSTLNEVG peptide conjugated to carrier protein |
Additional Info
| Function | Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function. Critical for spindle function and accurate chromosome segregation during mitosis since microtubule detyronisation regulates mitotic spindle length and postioning. Acts as an activator of angiogenesis: expressed in infiltrating mononuclear cells in the sprouting front to promote angiogenesis. Plays a role in axon formation. |
| Protein Name | Tubulinyl-Tyr Carboxypeptidase 2Vasohibin-2Vasohibin-Like Protein |
| Database Links | Reactome: R-HSA-8955332 |
| Cellular Localisation | CytoplasmSecretedCytoskeletonMainly Localizes In The CytoplasmSome Fraction Is Secreted Via A Non-Canonical Secretion SystemInteraction With Svbp Promotes SecretionAssociates With Microtubules |
| Alternative Antibody Names | Anti-Tubulinyl-Tyr Carboxypeptidase 2 antibodyAnti-Vasohibin-2 antibodyAnti-Vasohibin-Like Protein antibodyAnti-VASH2 antibodyAnti-VASHL antibody |
Information sourced from Uniprot.org