| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Tubulinyl-Tyr carboxypeptidase 1 (261-310 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000ELISA 1:40000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
VASH1 |
| Gene ID: |
22846 |
| Uniprot ID: |
VASH1_HUMAN |
| Immunogen Region: |
261-310 aa |
| Specificity: |
Vasohibin Polyclonal Antibody detects endogenous levels of Vasohibin protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the human VASH1 at the amino acid range 261-310 |
| Post Translational Modifications | 2 major forms (42 and 36 kDa) and 2 minors (32 and 27 kDa) may be processed by proteolytic cleavage. The largest form (42 kDa) seems to be secreted and the other major form (63 kDa) seems to accumulate within the cells or pericellular milieu. Polypeptide consisting of Met-77 to Arg-318 may correspond to the 27 kDa form and that consisting of Met-77 to Val-365 may correspond to the 36 kDa form. Ubiquitinated in vitro. |
| Function | Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function. Critical for spindle function and accurate chromosome segregation during mitosis since microtubule detyronisation regulates mitotic spindle length and postioning. Acts as an angiogenesis inhibitor: inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis. This inhibitory effect is selective to endothelial cells as it does not affect the migration of smooth muscle cells or fibroblasts. |
| Protein Name | Tubulinyl-Tyr Carboxypeptidase 1Tubulin Carboxypeptidase 1Tyrosine Carboxypeptidase 1Ttcp 1Vasohibin-1 |
| Database Links | Reactome: R-HSA-8955332 |
| Cellular Localisation | CytoplasmSecretedMainly Localizes In The CytoplasmSome Fraction Is Secreted Via A Non-Canonical Secretion SystemInteraction With Svbp Promotes Secretion |
| Alternative Antibody Names | Anti-Tubulinyl-Tyr Carboxypeptidase 1 antibodyAnti-Tubulin Carboxypeptidase 1 antibodyAnti-Tyrosine Carboxypeptidase 1 antibodyAnti-Ttcp 1 antibodyAnti-Vasohibin-1 antibodyAnti-VASH1 antibodyAnti-KIAA1036 antibodyAnti-VASH antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
