Anti-UXT antibody (STJA0008017)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human UXT
General Information
| Short Description | Rabbit polyclonal anti-Protein UXT for use in WB in Human and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | UXT |
| Gene ID | 8409 |
| Uniprot ID | UXT_HUMAN |
| Immunogen | Synthesized peptide derived from human UXT |
| Specificity | This antibody detects endogenous levels of UXT at Human, Rat |
Additional Info
| Post Translational Modifications | Isoform 2: Ubiquitinated by E3 ubiquitin-protein ligase complex containing FBXO7.leading to proteasomal degradation. |
| Function | Involved in gene transcription regulation. Acts in concert with the corepressor URI1 to regulate androgen receptor AR-mediated transcription. Together with URI1, associates with chromatin to the NKX3-1 promoter region. Negatively regulates the transcriptional activity of the estrogen receptor ESR1 by inducing its translocation into the cytoplasm. May act as nuclear chaperone that facilitates the formation of the NF-kappa-B enhanceosome and thus positively regulates NF-kappa-B transcription activity. Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling. Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC. Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM. Isoform 1: Plays a role in protecting cells against TNF-alpha-induced apoptosis by preventing the recruitment of FADD and caspase 8 to the apoptotic complex I, composed of TRADD, TRAF2 and RIPK1/RIP. |
| Protein Name | Protein UxtAndrogen Receptor Trapped Clone 27 ProteinArt-27Ubiquitously Expressed Transcript Protein |
| Database Links | Reactome: R-HSA-8953750 |
| Cellular Localisation | Isoform 1: CytoplasmIsoform 2: NucleusCytoplasmNucleusCytoskeletonMicrotubule Organizing CenterCentrosomeSpindle PolePredominantly Localizes To The NucleusLocalizes To Spindle Pole During Mitosis |
| Alternative Antibody Names | Anti-Protein Uxt antibodyAnti-Androgen Receptor Trapped Clone 27 Protein antibodyAnti-Art-27 antibodyAnti-Ubiquitously Expressed Transcript Protein antibodyAnti-UXT antibodyAnti-HSPC024 antibody |
Information sourced from Uniprot.org