| Host: |
Rabbit |
| Applications: |
WB/IHC/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-USP9Y (2456-2555) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:100-1:500IHC-P 1:50-1:200IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
USP9Y |
| Gene ID: |
8287 |
| Uniprot ID: |
USP9Y_HUMAN |
| Immunogen Region: |
2456-2555 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 2456-2555 of human USP9X/USP9Y (NP_004645.2). |
| Immunogen Sequence: |
YFLERSHSARMTLAKACELC PEEEPDDQDAPDEHEPSPSE DAPLYPHSPASQYQQNNHVH GQPYTGPAAHHLNNPQKTGQ RTQENYEGNEEVSSPQMKDQ |
| Tissue Specificity | Widely expressed in embryonic and adult tissues. |
| Function | May function as a ubiquitin-protein or polyubiquitin hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Essential component of TGF-beta/BMP signaling cascade. Deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade. Deubiquitination of SMAD4 by USP9X re-empowers its competence to mediate TGF-beta signaling. |
| Protein Name | Probable Ubiquitin Carboxyl-Terminal Hydrolase Faf-YDeubiquitinating Enzyme Faf-YFat Facets Protein-Related - Y-LinkedUbiquitin Thioesterase Faf-YUbiquitin-Specific Protease 9 - Y ChromosomeUbiquitin-Specific-Processing Protease Faf-Y |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Probable Ubiquitin Carboxyl-Terminal Hydrolase Faf-Y antibodyAnti-Deubiquitinating Enzyme Faf-Y antibodyAnti-Fat Facets Protein-Related - Y-Linked antibodyAnti-Ubiquitin Thioesterase Faf-Y antibodyAnti-Ubiquitin-Specific Protease 9 - Y Chromosome antibodyAnti-Ubiquitin-Specific-Processing Protease Faf-Y antibodyAnti-USP9Y antibodyAnti-DFFRY antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
