Anti-USP6 antibody (142-155) (STJ72791)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-USP6 (142-155) is suitable for use in ELISA, Immunofluorescence and Flow Cytometry research applications. |
| Applications | Pep-ELISA/IF/FC |
| Host | Goat |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:4000.WB: Preliminary experiments in Human Testis, Prostate and Placenta lysates gave no specific signal but low background at antibody concentration up to 1µg/ml.IF: Strong expression of th |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | USP6 |
| Gene ID | 9098 |
| Uniprot ID | UBP6_HUMAN |
| Accession Number | NP_004496.2 |
| Immunogen Region | 142-155 |
| Immunogen Sequence | HHIDLDVRTTLRNH |
| Specificity | This antibody is expected NOT to cross react to USP32 or to the TBC1D3 proteins. |
Additional Info
| Post Translational Modifications | Monubiquitinated.ubiquitination is calmodulin and calcium dependent. |
| Function | Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity. Promotes plasma membrane localization of ARF6 and selectively regulates ARF6-dependent endocytic protein trafficking. Is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation. May act as a GTPase-activating protein for RAB3A. |
| Protein Name | Ubiquitin Carboxyl-Terminal Hydrolase 6Deubiquitinating Enzyme 6Proto-Oncogene Tre-2Rn-TreUbiquitin Thioesterase 6Ubiquitin-Specific-Processing Protease 6 |
| Cellular Localisation | Cell MembraneCytoplasmEndosomeLocalizes To The Plasma Membrane And To Filamentous Structures Within The Cell Corresponding To Arf6 Regulated Tubular EndosomesActivation Of Rac1 And Cdc42 Can Direct The Relocalization Of Usp6 To The Plasma Membrane In A Manner That Depends On The Integrity Of The Actin Cytoskeleton |
| Alternative Antibody Names | Anti-Ubiquitin Carboxyl-Terminal Hydrolase 6 antibodyAnti-Deubiquitinating Enzyme 6 antibodyAnti-Proto-Oncogene Tre-2 antibodyAnti-Rn-Tre antibodyAnti-Ubiquitin Thioesterase 6 antibodyAnti-Ubiquitin-Specific-Processing Protease 6 antibodyAnti-USP6 antibodyAnti-HRP1 antibodyAnti-TRE2 antibody |
Information sourced from Uniprot.org