• Immunofluorescence analysis of U-2 OS cells using USP39 Rabbit monoclonal antibody (STJ11103488) at dilution of 1:100 (40x lens). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.
  • Immunofluorescence analysis of PC-12 cells using USP39 Rabbit monoclonal antibody (STJ11103488) at dilution of 1:100 (40x lens). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.
  • Immunofluorescence analysis of NIH/3T3 cells using USP39 Rabbit monoclonal antibody (STJ11103488) at dilution of 1:100 (40x lens). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.
  • Immunohistochemistry analysis of USP39 in paraffin-embedded rat spleen tissue using USP39 Rabbit monoclonal antibody (STJ11103488) at a dilution of 1:200 (40x lens). High pressure antigen retrieval was performed with 0. 01 M citrate buffer (pH 6. 0) prior to immunohistochemistry staining.
  • Immunohistochemistry analysis of USP39 in paraffin-embedded mouse kidney tissue using USP39 Rabbit monoclonal antibody (STJ11103488) at a dilution of 1:200 (40x lens). High pressure antigen retrieval was performed with 0. 01 M citrate buffer (pH 6. 0) prior to immunohistochemistry staining.
  • Immunohistochemistry analysis of USP39 in paraffin-embedded rat brain tissue using USP39 Rabbit monoclonal antibody (STJ11103488) at a dilution of 1:200 (40x lens). High pressure antigen retrieval was performed with 0. 01 M citrate buffer (pH 6. 0) prior to immunohistochemistry staining.
  • Immunohistochemistry analysis of USP39 in paraffin-embedded mouse lung tissue using USP39 Rabbit monoclonal antibody (STJ11103488) at a dilution of 1:200 (40x lens). High pressure antigen retrieval was performed with 0. 01 M citrate buffer (pH 6. 0) prior to immunohistochemistry staining.
  • Immunohistochemistry analysis of USP39 in paraffin-embedded mouse brain tissue using USP39 Rabbit monoclonal antibody (STJ11103488) at a dilution of 1:200 (40x lens). High pressure antigen retrieval was performed with 0. 01 M citrate buffer (pH 6. 0) prior to immunohistochemistry staining.
  • Immunohistochemistry analysis of USP39 in paraffin-embedded human colon carcinoma tissue using USP39 Rabbit monoclonal antibody (STJ11103488) at a dilution of 1:200 (40x lens). High pressure antigen retrieval was performed with 0. 01 M citrate buffer (pH 6. 0) prior to immunohistochemistry staining.
  • Immunohistochemistry analysis of USP39 in paraffin-embedded mouse testis tissue using USP39 Rabbit monoclonal antibody (STJ11103488) at a dilution of 1:200 (40x lens). High pressure antigen retrieval was performed with 0. 01 M citrate buffer (pH 6. 0) prior to immunohistochemistry staining.
  • Immunohistochemistry analysis of USP39 in paraffin-embedded human thyroid cancer tissue using USP39 Rabbit monoclonal antibody (STJ11103488) at a dilution of 1:200 (40x lens). High pressure antigen retrieval was performed with 0. 01 M citrate buffer (pH 6. 0) prior to immunohistochemistry staining.
  • Immunohistochemistry analysis of USP39 in paraffin-embedded mouse intestin tissue using USP39 Rabbit monoclonal antibody (STJ11103488) at a dilution of 1:200 (40x lens). High pressure antigen retrieval was performed with 0. 01 M citrate buffer (pH 6. 0) prior to immunohistochemistry staining.
  • Immunohistochemistry analysis of USP39 in paraffin-embedded human spleen tissue using USP39 Rabbit monoclonal antibody (STJ11103488) at a dilution of 1:200 (40x lens). High pressure antigen retrieval was performed with 0. 01 M citrate buffer (pH 6. 0) prior to immunohistochemistry staining.
  • Western blot analysis of lysates from mouse liver, using USP39 Rabbit monoclonal antibody (STJ11103488) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.

Anti-USP39 antibody (466-565) [S8MR] (STJ11103488)

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STJ11103488

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Host: Rabbit
Applications: WB/IHC/IF
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit monoclonal antibody anti-USP39 (466-565) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications.
Clonality: Monoclonal
Clone ID: S8MR
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
IHC-P 1:50-1:200
IF/ICC 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: USP39
Gene ID: 10713
Uniprot ID: UBP39_HUMAN
Immunogen Region: 466-565
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 466-565 of Human USP39 (Q53GS9).
Immunogen Sequence: KNPTIVNFPITNVDLREYLS EEVQAVHKNTTYDLIANIVH DGKPSEGSYRIHVLHHGTGK WYELQDLQVTDILPQMITLS EAYIQIWKRRDNDETNQQGA
Function Deubiquitinating enzyme that plays a role in many cellular processes including cellular antiviral response, epithelial morphogenesis, DNA repair or B-cell development. Plays a role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the precatalytic spliceosome. Specifically regulates immunoglobulin gene rearrangement in a spliceosome-dependent manner, which involves modulating chromatin interactions at the Igh locus and therefore plays an essential role in B-cell development. Regulates AURKB mRNA levels, and thereby plays a role in cytokinesis and in the spindle checkpoint. Regulates apoptosis and G2/M cell cycle checkpoint in response to DNA damage by deubiquitinating and stabilizing CHK2. Plays also an important role in DNA repair by controlling the recruitment of XRCC4/LIG4 to DNA double-strand breaks for non-homologous end-joining repair. Participates in antiviral activity by affecting the type I IFN signaling by stabilizing STAT1 and decreasing its 'Lys-6'-linked ubiquitination. Contributes to non-canonical Wnt signaling during epidermal differentiation. Acts as a negative regulator NF-kappa-B activation through deubiquitination of 'Lys-48'-linked ubiquitination of NFKBIA.
Protein Name Ubiquitin Carboxyl-Terminal Hydrolase 39
Sad1 Homolog
U4/U6.U5 Tri-Snrnp-Associated 65 Kda Protein
Database Links Reactome: R-HSA-72163
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Ubiquitin Carboxyl-Terminal Hydrolase 39 antibody
Anti-Sad1 Homolog antibody
Anti-U4/U6.U5 Tri-Snrnp-Associated 65 Kda Protein antibody
Anti-USP39 antibody
Anti-CGI-21 antibody
Anti-HSPC332 antibody
Anti-PRO2855 antibody

Information sourced from Uniprot.org

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