Anti-USP39 antibody (336-565) (STJ111753)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal USP39 (336-565) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | USP39 |
| Gene ID | 10713 |
| Uniprot ID | UBP39_HUMAN |
| Immunogen Region | 336-565 |
| Immunogen Sequence | GTKKKKKTIVTDVFQGSMRI FTKKLPHPDLPAEEKEQLLH NDEYQETMVESTFMYLTLDL PTAPLYKDEKEQLIIPQVPL FNILAKFNGITEKEYKTYKE NFLKRFQLTKLPPYLIFCIK RFTKNNFFVEKNPTIVNFPI TNVDLREYLSEEVQAVHKNT TYDLIANIVHDGKPSEGSYR IHVLHHGTGKWYELQDLQVT DILPQMITLSEAYIQIWKRR DNDETNQQGA |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 336-565 of human USP39 (NP_006581.2). |
Additional Info
| Function | Deubiquitinating enzyme that plays a role in many cellular processes including cellular antiviral response, epithelial morphogenesis, DNA repair or B-cell development. Plays a role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the precatalytic spliceosome. Specifically regulates immunoglobulin gene rearrangement in a spliceosome-dependent manner, which involves modulating chromatin interactions at the Igh locus and therefore plays an essential role in B-cell development. Regulates AURKB mRNA levels, and thereby plays a role in cytokinesis and in the spindle checkpoint. Regulates apoptosis and G2/M cell cycle checkpoint in response to DNA damage by deubiquitinating and stabilizing CHK2. Also plays an important role in DNA repair by controlling the recruitment of XRCC4/LIG4 to DNA double-strand breaks for non-homologous end-joining repair. Participates in antiviral activity by affecting the type I IFN signaling by stabilizing STAT1 and decreasing its 'Lys-6'-linked ubiquitination. Contributes to non-canonical Wnt signaling during epidermal differentiation. Acts as a negative regulator NF-kappa-B activation through deubiquitination of 'Lys-48'-linked ubiquitination of NFKBIA. |
| Protein Name | Ubiquitin Carboxyl-Terminal Hydrolase 39Sad1 HomologU4/U6.U5 Tri-Snrnp-Associated 65 Kda Protein |
| Database Links | Reactome: R-HSA-72163 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Ubiquitin Carboxyl-Terminal Hydrolase 39 antibodyAnti-Sad1 Homolog antibodyAnti-U4/U6.U5 Tri-Snrnp-Associated 65 Kda Protein antibodyAnti-USP39 antibodyAnti-CGI-21 antibodyAnti-HSPC332 antibodyAnti-PRO2855 antibody |
Information sourced from Uniprot.org