| Tissue Specificity | Expressed in brain at low level. |
| Function | Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. |
| Protein Name | Ubiquitin Carboxyl-Terminal Hydrolase 34Deubiquitinating Enzyme 34Ubiquitin Thioesterase 34Ubiquitin-Specific-Processing Protease 34 |
| Database Links | Reactome: R-HSA-201681Reactome: R-HSA-5689880 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Ubiquitin Carboxyl-Terminal Hydrolase 34 antibodyAnti-Deubiquitinating Enzyme 34 antibodyAnti-Ubiquitin Thioesterase 34 antibodyAnti-Ubiquitin-Specific-Processing Protease 34 antibodyAnti-USP34 antibodyAnti-KIAA0570 antibodyAnti-KIAA0729 antibody |
Information sourced from Uniprot.org
