Anti-USP21 antibody (N-Term) (STJ71619)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-USP21 (N-Term) is suitable for use in ELISA research applications. |
| Applications | Pep-ELISA |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Cow |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:64000.WB: Preliminary experiments in Human Thyroid, Thymus and Tonsil lysates gave no specific signal but low background (at antibody concentration up to 1µg/ml). We would appreciate any feedbac |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | USP21 |
| Gene ID | 27005 |
| Uniprot ID | UBP21_HUMAN |
| Accession Number | NP_036607.3 |
| Immunogen Region | N-Term |
| Immunogen Sequence | GRTREPPVNIQP |
| Specificity | Reported variants represent identical protein: NP_001014443.1 NP_036607.3 |
Additional Info
| Function | Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination. Deubiquitinates BAZ2A/TIP5 leading to its stabilization. Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates. Also acts as a negative regulator of the ribosome quality control (RQC) by mediating deubiquitination of 40S ribosomal proteins RPS10/eS10 and RPS20/uS10, thereby antagonizing ZNF598-mediated 40S ubiquitination. |
| Protein Name | Ubiquitin Carboxyl-Terminal Hydrolase 21Deubiquitinating Enzyme 21Ubiquitin Thioesterase 21Ubiquitin-Specific-Processing Protease 21 |
| Database Links | Reactome: R-HSA-5357786Reactome: R-HSA-5357905Reactome: R-HSA-5357956Reactome: R-HSA-5689880 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Ubiquitin Carboxyl-Terminal Hydrolase 21 antibodyAnti-Deubiquitinating Enzyme 21 antibodyAnti-Ubiquitin Thioesterase 21 antibodyAnti-Ubiquitin-Specific-Processing Protease 21 antibodyAnti-USP21 antibodyAnti-USP23 antibodyAnti-PP1490 antibody |
Information sourced from Uniprot.org