Western blot analysis of lysates from Hela cells, primary antibody was diluted at 1:1000, 4°C over night

Anti-USP21 antibody (50-100 aa) (STJ193589)

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STJ193589
€60.00 - €315.00
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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-Ubiquitin carboxyl-terminal hydrolase 21 (50-100 aa) is suitable for use in Western Blot research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: USP21
Gene ID: 27005
Uniprot ID: UBP21_HUMAN
Immunogen Region: 50-100 aa
Specificity: This antibody detects endogenous levels of UBP21 at Human/Mouse/Rat
Immunogen: Synthesized peptide derived from the human UBP21 at the amino acid range 50-100
Function Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination. Deubiquitinates BAZ2A/TIP5 leading to its stabilization. Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates. Also acts as a negative regulator of the ribosome quality control (RQC) by mediating deubiquitination of 40S ribosomal proteins RPS10/eS10 and RPS20/uS10, thereby antagonizing ZNF598-mediated 40S ubiquitination.
Protein Name Ubiquitin Carboxyl-Terminal Hydrolase 21
Deubiquitinating Enzyme 21
Ubiquitin Thioesterase 21
Ubiquitin-Specific-Processing Protease 21
Database Links Reactome: R-HSA-5357786
Reactome: R-HSA-5357905
Reactome: R-HSA-5357956
Reactome: R-HSA-5689880
Cellular Localisation Cytoplasm
Nucleus
Alternative Antibody Names Anti-Ubiquitin Carboxyl-Terminal Hydrolase 21 antibody
Anti-Deubiquitinating Enzyme 21 antibody
Anti-Ubiquitin Thioesterase 21 antibody
Anti-Ubiquitin-Specific-Processing Protease 21 antibody
Anti-USP21 antibody
Anti-USP23 antibody
Anti-PP1490 antibody

Information sourced from Uniprot.org

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