Anti-USP21 antibody (1-18) (STJ119081)

Name: Anti-USP21 antibody (1-18) (STJ119081)
SKU: STJ119081
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ119081

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Short Description	Rabbit polyclonal USP21 (1-18) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/IF/ICC/ELISA
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:1000 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	USP21
Gene ID	27005
Uniprot ID	UBP21_HUMAN
Immunogen Region	1-18
Immunogen Sequence	MPQASEHRLGRTREPPVNIQ PRVGSKLPFAPRARSKERRN PASGPNPMLRPLPPRPGLPD ERLKKLELGRGRTSGPRPRG PLRADHGVPLPGSPPPTVAL
Specificity	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human USP21 (NP_036607.3).

Tissue Specificity	Highly expressed in heart, pancreas and skeletal muscle. Also expressed in brain, placenta, liver and kidney, and at very low level in lung.
Function	Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination. Deubiquitinates BAZ2A/TIP5 leading to its stabilization. Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates. Also acts as a negative regulator of the ribosome quality control (RQC) by mediating deubiquitination of 40S ribosomal proteins RPS10/eS10 and RPS20/uS10, thereby antagonizing ZNF598-mediated 40S ubiquitination.
Protein Name	Ubiquitin Carboxyl-Terminal Hydrolase 21 Deubiquitinating Enzyme 21 Ubiquitin Thioesterase 21 Ubiquitin-Specific-Processing Protease 21
Database Links	Reactome: R-HSA-5357786 Reactome: R-HSA-5357905 Reactome: R-HSA-5357956 Reactome: R-HSA-5689880
Cellular Localisation	Cytoplasm Nucleus
Alternative Antibody Names	Anti-Ubiquitin Carboxyl-Terminal Hydrolase 21 antibody Anti-Deubiquitinating Enzyme 21 antibody Anti-Ubiquitin Thioesterase 21 antibody Anti-Ubiquitin-Specific-Processing Protease 21 antibody Anti-USP21 antibody Anti-USP23 antibody Anti-PP1490 antibody

Information sourced from Uniprot.org