Anti-USP11 antibody (70-190) (STJ11103210)

Name: Anti-USP11 antibody (70-190) (STJ11103210)
SKU: STJ11103210
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ11103210

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Short Description	Rabbit polyclonal USP11 (70-190) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/IF/ICC/ELISA
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:1000 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	USP11Uniprot ID=UBP11_HUMAN"
Immunogen Region	70-190
Immunogen Sequence	PQHEELPGLDSQWRQIENGE SGRERPLRAGESWFLVEKHW YKQWEAYVQGGDQDSSTFPG CINNATLFQDEINWRLKEGL VEGEDYVLLPAAAWHYLVSW YGLEHGQPPIERKVIELPNI Q
Specificity	Recombinant fusion protein containing a sequence corresponding to amino acids 70-190 of human USP11 (NP_004642.2).

Function	Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Cleaves preferentially 'Lys-6' and 'Lys-63'-linked ubiquitin chains. Has lower activity with 'Lys-11' and 'Lys-33'-linked ubiquitin chains, and extremely low activity with 'Lys-27', 'Lys-29' and 'Lys-48'-linked ubiquitin chains (in vitro). Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA breaks. Acts as a chromatin regulator via its association with the Polycomb group (PcG) multiprotein PRC1-like complex.may act by deubiquitinating components of the PRC1-like complex. Promotes cell proliferation by deubiquitinating phosphorylated E2F1.
Protein Name	Ubiquitin Carboxyl-Terminal Hydrolase 11 Deubiquitinating Enzyme 11 Ubiquitin Thioesterase 11 Ubiquitin-Specific-Processing Protease 11
Cellular Localisation	Nucleus Cytoplasm Chromosome Predominantly Nuclear Associates With Chromatin
Alternative Antibody Names	Anti-Ubiquitin Carboxyl-Terminal Hydrolase 11 antibody Anti-Deubiquitinating Enzyme 11 antibody Anti-Ubiquitin Thioesterase 11 antibody Anti-Ubiquitin-Specific-Processing Protease 11 antibody Anti-USP11 antibody Anti-UHX1 antibody

Information sourced from Uniprot.org