| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-USP11 (70-190) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
USP11Uniprot ID=UBP11_HUMAN" |
| Immunogen Region: |
70-190 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 70-190 of human USP11 (NP_004642.2). |
| Immunogen Sequence: |
PQHEELPGLDSQWRQIENGE SGRERPLRAGESWFLVEKHW YKQWEAYVQGGDQDSSTFPG CINNATLFQDEINWRLKEGL VEGEDYVLLPAAAWHYLVSW YGLEHGQPPIERKVIELPNI Q |
| Function | Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Cleaves preferentially 'Lys-6' and 'Lys-63'-linked ubiquitin chains. Has lower activity with 'Lys-11' and 'Lys-33'-linked ubiquitin chains, and extremely low activity with 'Lys-27', 'Lys-29' and 'Lys-48'-linked ubiquitin chains (in vitro). Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA breaks. Acts as a chromatin regulator via its association with the Polycomb group (PcG) multiprotein PRC1-like complex.may act by deubiquitinating components of the PRC1-like complex. Promotes cell proliferation by deubiquitinating phosphorylated E2F1. |
| Protein Name | Ubiquitin Carboxyl-Terminal Hydrolase 11Deubiquitinating Enzyme 11Ubiquitin Thioesterase 11Ubiquitin-Specific-Processing Protease 11 |
| Cellular Localisation | NucleusCytoplasmChromosomePredominantly NuclearAssociates With Chromatin |
| Alternative Antibody Names | Anti-Ubiquitin Carboxyl-Terminal Hydrolase 11 antibodyAnti-Deubiquitinating Enzyme 11 antibodyAnti-Ubiquitin Thioesterase 11 antibodyAnti-Ubiquitin-Specific-Processing Protease 11 antibodyAnti-USP11 antibodyAnti-UHX1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
