Anti-USP11 antibody (800-900) [S9MR] (STJ11103039)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal USP11 (800-900) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S9MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | USP11Uniprot ID=UBP11_HUMAN" |
| Immunogen Region | 800-900 |
| Immunogen Sequence | WYCPSCKQHQLATKKLDLWM LPEILIIHLKRFSYTKFSRE KLDTLVEFPIRDLDFSEFVI QPQNESNPELYKYDLIAVSN HYGGMRDGHYTTFACNKDSG Q |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 800-900 of human USP11 (P51784). |
Additional Info
| Function | Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Cleaves preferentially 'Lys-6' and 'Lys-63'-linked ubiquitin chains. Has lower activity with 'Lys-11' and 'Lys-33'-linked ubiquitin chains, and extremely low activity with 'Lys-27', 'Lys-29' and 'Lys-48'-linked ubiquitin chains (in vitro). Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA breaks. Acts as a chromatin regulator via its association with the Polycomb group (PcG) multiprotein PRC1-like complex.may act by deubiquitinating components of the PRC1-like complex. Promotes cell proliferation by deubiquitinating phosphorylated E2F1. |
| Protein Name | Ubiquitin Carboxyl-Terminal Hydrolase 11Deubiquitinating Enzyme 11Ubiquitin Thioesterase 11Ubiquitin-Specific-Processing Protease 11 |
| Cellular Localisation | NucleusCytoplasmChromosomePredominantly NuclearAssociates With Chromatin |
| Alternative Antibody Names | Anti-Ubiquitin Carboxyl-Terminal Hydrolase 11 antibodyAnti-Deubiquitinating Enzyme 11 antibodyAnti-Ubiquitin Thioesterase 11 antibodyAnti-Ubiquitin-Specific-Processing Protease 11 antibodyAnti-USP11 antibodyAnti-UHX1 antibody |
Information sourced from Uniprot.org