Anti-USH2A antibody (255-305) (STJ503474)

SKU:
STJ503474-100

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Host: Rabbit
Applications: CM/ELISA/ICC/IF/IHC/IP/WB
Reactivity: Human/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-USH2A (255-305) is suitable for use in Confocal Microscopy, ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.62 µg/µl
Dilution Range: WB: 1:500
DB: 1:4, 000
ELISA: 1:4, 000
IP: 1:200
IHC: 1:250
ICC: 1:250
IF: 1:250
CFM: 1:250
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: USH2A
Gene ID: 7399
Uniprot ID: USH2A_HUMAN
Immunogen Region: 255-305
Specificity: This antibody will detect both Usherin isoform A and Usherin isoform B.
Immunogen: Synthetic peptide taken within amino acid region 255-305 on human Usherin isoform A protein.
Tissue Specificity Present in the basement membrane of many, but not all tissues. Expressed in retina, cochlea, small and large intestine, pancreas, bladder, prostate, esophagus, trachea, thymus, salivary glands, placenta, ovary, fallopian tube, uterus and testis. Absent in many other tissues such as heart, lung, liver, kidney and brain. In the retina, it is present in the basement membranes in the Bruch's layer choroid capillary basement membranes, where it localizes just beneath the retinal pigment epithelial cells (at protein level). Weakly expressed. Isoform 2 is expressed in fetal eye, cochlea and heart, and at very low level in brain, CNS, intestine, skeleton, tongue, kidney and lung. Isoform 2 is not expressed in stomach and liver. In adult tissues, isoform 2 is expressed in neural retina and testis, and at low level in brain, heart, kidney and liver. Isoform 1 displays a similar pattern of expression but is expressed at very low level in fetal cochlea.
Function Involved in hearing and vision as member of the USH2 complex. In the inner ear, required for the maintenance of the hair bundle ankle formation, which connects growing stereocilia in developing cochlear hair cells. In retina photoreceptors, the USH2 complex is required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport.
Protein Name Usherin
Usher Syndrome Type Iia Protein
Usher Syndrome Type-2a Protein
Cellular Localisation Cell Projection
Stereocilium Membrane
Single-Pass Type I Membrane Protein
Component Of The Interstereocilia Ankle Links In The Inner Ear Sensory Cells
In Photoreceptors
Localizes At A Plasma Membrane Microdomain In The Apical Inner Segment That Surrounds The Connecting Cilia Called Periciliary Membrane Complex
Isoform 2: Secreted
Alternative Antibody Names Anti-Usherin antibody
Anti-Usher Syndrome Type Iia Protein antibody
Anti-Usher Syndrome Type-2a Protein antibody
Anti-USH2A antibody

Information sourced from Uniprot.org

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