Anti-USH1C antibody (STJA0008197)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human Harmonin
General Information
| Short Description | Rabbit polyclonal anti-Harmonin for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | USH1C |
| Gene ID | 10083 |
| Uniprot ID | USH1C_HUMAN |
| Immunogen | Synthesized peptide derived from human Harmonin |
| Specificity | This antibody detects endogenous levels of Harmonin at Human, Mouse |
Additional Info
| Function | Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal development and maintenance of cochlear hair cell bundles. As part of the intermicrovillar adhesion complex/IMAC plays a role in brush border differentiation, controlling microvilli organization and length. Probably plays a central regulatory role in the assembly of the complex, recruiting CDHR2, CDHR5 and MYO7B to the microvilli tips. |
| Protein Name | HarmoninAntigen Ny-Co-38/Ny-Co-37Autoimmune Enteropathy-Related Antigen Aie-75Protein Pdz-73Renal Carcinoma Antigen Ny-Ren-3Usher Syndrome Type-1c Protein |
| Database Links | Reactome: R-HSA-9662360Reactome: R-HSA-9662361 |
| Cellular Localisation | CytoplasmCytosolCytoskeletonCell ProjectionMicrovillusColocalizes With F-ActinDetected At The Tip Of Cochlear Hair Cell StereociliaEnriched In Microvilli Of The Intestinal Brush Border |
| Alternative Antibody Names | Anti-Harmonin antibodyAnti-Antigen Ny-Co-38/Ny-Co-37 antibodyAnti-Autoimmune Enteropathy-Related Antigen Aie-75 antibodyAnti-Protein Pdz-73 antibodyAnti-Renal Carcinoma Antigen Ny-Ren-3 antibodyAnti-Usher Syndrome Type-1c Protein antibodyAnti-USH1C antibodyAnti-AIE75 antibody |
Information sourced from Uniprot.org