| Tissue Specificity | Expressed in the spinal cord, ganglia, choroid plexus and olfactors epithelium of the developing brain. Expressed in skin, lung, kidney, testis and muscles (at protein level). Expressed strongly in brain and kidney. Expressed weakly in skeletal muscle, lung and liver. |
| Post Translational Modifications | Phosphorylation occurs in response to androgen treatment in prostate cancer cells in a mTOR-dependent manner. Phosphorylated.hyperhosphorylated in mitochondria in a mTORC-dependent signaling pathway. Phosphorylated at Ser-369 by RPS6KB1 in a growth factor- and rapamycin-dependent manner. S6K1-mediated mitochondrial phosphorylation at Ser-369 disrupts the URI1-PPP1CC complex in the mitochondrion, relieves PPP1CC phosphatase inhibition activity and hence engages a negative feedback diminishing RPS6KB1 kinase activity, preventing sustained S6K1-dependent signaling. Phosphorylated. Phosphorylation occurs essentially on serine residues. |
| Function | Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination. |
| Protein Name | Unconventional Prefoldin Rpb5 InteractorProtein Nnx3Protein Phosphatase 1 Regulatory Subunit 19Rna Polymerase Ii Subunit 5-Mediating ProteinRpb5-Mediating Protein |
| Cellular Localisation | NucleusCytoplasmMitochondrionCell ProjectionDendriteColocalizes With Pfdn2Pfdn4Ppp1ccRps6kb1 And Stap1 In Mitochondrion |
| Alternative Antibody Names | Anti-Unconventional Prefoldin Rpb5 Interactor antibodyAnti-Protein Nnx3 antibodyAnti-Protein Phosphatase 1 Regulatory Subunit 19 antibodyAnti-Rna Polymerase Ii Subunit 5-Mediating Protein antibodyAnti-Rpb5-Mediating Protein antibodyAnti-Uri1 antibodyAnti-Nnx3 antibodyAnti-Ppp1r19 antibodyAnti-Rmp antibodyAnti-Uri antibody |
Information sourced from Uniprot.org
