Anti-UQCRH antibody [R42-3F-2] (STJA0035578)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human UQCRH
General Information
| Short Description | Rabbit monoclonal anti-UQCRH for use in WB and IHC-P in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R42-3F-2 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Chromatography |
| Dilution Range | WB 1:500-1:1000IHC 1:100-1:200 |
| Formulation | Liquid in PBS, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | UQCRH |
| Gene ID | 7388 |
| Uniprot ID | QCR6_HUMAN |
| Immunogen | A synthesized peptide derived from human UQCRH |
Additional Info
| Function | Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. |
| Protein Name | Cytochrome B-C1 Complex Subunit 6 - MitochondrialComplex Iii Subunit 6Complex Iii Subunit ViiiCytochrome C1 Non-Heme 11 Kda ProteinMitochondrial Hinge ProteinUbiquinol-Cytochrome C Reductase Complex 11 Kda Protein |
| Database Links | Reactome: R-HSA-611105Reactome: R-HSA-9865881 |
| Cellular Localisation | Mitochondrion Inner MembranePeripheral Membrane ProteinIntermembrane Side |
| Alternative Antibody Names | Anti-Cytochrome B-C1 Complex Subunit 6 - Mitochondrial antibodyAnti-Complex Iii Subunit 6 antibodyAnti-Complex Iii Subunit Viii antibodyAnti-Cytochrome C1 Non-Heme 11 Kda Protein antibodyAnti-Mitochondrial Hinge Protein antibodyAnti-Ubiquinol-Cytochrome C Reductase Complex 11 Kda Protein antibodyAnti-UQCRH antibody |
Information sourced from Uniprot.org