Anti-UPF3A antibody (190-240 aa) (STJ194832)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human REN3A at the amino acid range 190-240
General Information
| Short Description | Rabbit polyclonal anti-Regulator of nonsense transcripts 3A (190-240 aa) for use in WB and IHC in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC-P 1:50-300 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | UPF3A |
| Gene ID | 65110 |
| Uniprot ID | REN3A_HUMAN |
| Immunogen | Synthesized peptide derived from the human REN3A at the amino acid range 190-240 |
| Immunogen Region | 190-240 aa |
| Specificity | This antibody detects endogenous levels of REN3A at Human |
Additional Info
| Function | Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. However, UPF3A is shown to be only marginally active in NMD as compared to UPF3B. Binds spliced mRNA upstream of exon-exon junctions. In vitro, weakly stimulates translation. |
| Protein Name | Regulator Of Nonsense Transcripts 3aNonsense Mrna Reducing Factor 3aUp-Frameshift Suppressor 3 Homolog AHupf3 |
| Database Links | Reactome: R-HSA-9010553Reactome: R-HSA-975957 Q9H1J1-2 |
| Cellular Localisation | NucleusCytoplasmShuttling Between The Nucleus And The Cytoplasm |
| Alternative Antibody Names | Anti-Regulator Of Nonsense Transcripts 3a antibodyAnti-Nonsense Mrna Reducing Factor 3a antibodyAnti-Up-Frameshift Suppressor 3 Homolog A antibodyAnti-Hupf3 antibodyAnti-UPF3A antibodyAnti-RENT3A antibodyAnti-UPF3 antibody |
Information sourced from Uniprot.org