| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Regulator of nonsense transcripts 3A (190-240 aa) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000IHC-P 1:50-300 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
UPF3A |
| Gene ID: |
65110 |
| Uniprot ID: |
REN3A_HUMAN |
| Immunogen Region: |
190-240 aa |
| Specificity: |
This antibody detects endogenous levels of REN3A at Human |
| Immunogen: |
Synthesized peptide derived from the human REN3A at the amino acid range 190-240 |
| Function | Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. However, UPF3A is shown to be only marginally active in NMD as compared to UPF3B. Binds spliced mRNA upstream of exon-exon junctions. In vitro, weakly stimulates translation. |
| Protein Name | Regulator Of Nonsense Transcripts 3aNonsense Mrna Reducing Factor 3aUp-Frameshift Suppressor 3 Homolog AHupf3 |
| Database Links | Reactome: R-HSA-9010553Reactome: R-HSA-975957 Q9H1J1-2 |
| Cellular Localisation | NucleusCytoplasmShuttling Between The Nucleus And The Cytoplasm |
| Alternative Antibody Names | Anti-Regulator Of Nonsense Transcripts 3a antibodyAnti-Nonsense Mrna Reducing Factor 3a antibodyAnti-Up-Frameshift Suppressor 3 Homolog A antibodyAnti-Hupf3 antibodyAnti-UPF3A antibodyAnti-RENT3A antibodyAnti-UPF3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
