| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-UNC93B1 (450-550) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
UNC93B1 |
| Gene ID: |
81622 |
| Uniprot ID: |
UN93B_HUMAN |
| Immunogen Region: |
450-550 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 450-550 of human UNC93B1 (NP_112192.2). |
| Immunogen Sequence: |
KTGLSTLLGILYEDKERQDF IFTIYHWWQAVAIFTVYLGS SLHMKAKLAVLLVTLVAAAV SYLRMEQKLRRGVAPRQPRI PRPQHKVRGYRYLEEDNSDE S |
| Tissue Specificity | Expressed in plasmocytoid dendritic cells (at protein level). Highly expressed in antigen-presenting cells. Expressed in heart, and at lower level in kidney. Expressed at low level in other tissues. |
| Post Translational Modifications | N-glycosylated. |
| Function | Plays an important role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like receptor (TLR) signaling. Required for the transport of a subset of TLRs (including TLR3, TLR7 and TLR9) from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. May play a role in autoreactive B-cells removal. |
| Protein Name | Protein Unc-93 Homolog B1Unc-93b1Hunc93b1 |
| Database Links | Reactome: R-HSA-1679131Reactome: R-HSA-5602415 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinEndosomeLysosomeCytoplasmic VesiclePhagosomeRelocalizes From Endoplasmic Reticulum To Endosome And Lysosome Upon Cell-Stimulation With Cpg DinucleotidesColocalizes With Lamp5 In Large Endosomal Intracellular Vesicles |
| Alternative Antibody Names | Anti-Protein Unc-93 Homolog B1 antibodyAnti-Unc-93b1 antibodyAnti-Hunc93b1 antibodyAnti-UNC93B1 antibodyAnti-UNC93 antibodyAnti-UNC93B antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
