Anti-Unc5b-Mouse, Rat antibody (Internal) (STJ72873)

SKU:
STJ72873-100

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Host: Goat
Applications: Pep-ELISA
Reactivity: Human/Mouse/Rat/Dog/Cow
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-Unc5b-Mouse, Rat (Internal) is suitable for use in ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: ELISA-antibody detection limit dilution 1:16000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: UNC5B
Gene ID: 219699
Uniprot ID: UNC5B_HUMAN
Immunogen Region: Internal
Accession Number: NP_084046.2
Specificity: This antibody is expected to recognize the cytoplasmic domain of the protein.
Immunogen Sequence: DWIFQLKTQAHQGH
Post Translational Modifications Phosphorylated on cytoplasmic tyrosine residues. Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis. Palmitoylation is required for pro-apoptotic activity, but not for location at lipid rafts.
Function Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Functions as netrin receptor that negatively regulates vascular branching during angiogenesis. Mediates retraction of tip cell filopodia on endothelial growth cones in response to netrin. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity.
Protein Name Netrin Receptor Unc5b
Protein Unc-5 Homolog 2
Protein Unc-5 Homolog B
P53-Regulated Receptor For Death And Life Protein 1
P53rdl1
Database Links Reactome: R-HSA-373752
Reactome: R-HSA-418886
Reactome: R-HSA-418889
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Membrane Raft
Associated With Lipid Rafts
Alternative Antibody Names Anti-Netrin Receptor Unc5b antibody
Anti-Protein Unc-5 Homolog 2 antibody
Anti-Protein Unc-5 Homolog B antibody
Anti-P53-Regulated Receptor For Death And Life Protein 1 antibody
Anti-P53rdl1 antibody
Anti-UNC5B antibody
Anti-P53RDL1 antibody
Anti-UNC5H2 antibody
Anti-UNQ1883 antibody
Anti-PRO4326 antibody

Information sourced from Uniprot.org

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