Anti-UNC5A antibody (130-210 aa) (STJ191048)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 130-210
General Information
| Short Description | Rabbit polyclonal anti-Netrin receptor UNC5A (130-210 aa) for use in WB and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | UNC5A |
| Gene ID | 90249 |
| Uniprot ID | UNC5A_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 130-210 |
| Immunogen Region | 130-210 aa |
| Specificity | UNC5A Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | Receptor for netrin required for axon guidance. Functions in the netrin signaling pathway and promotes neurite outgrowth in response to NTN1. Mediates axon repulsion of neuronal growth cones in the developing nervous system in response to netrin. Axon repulsion in growth cones may be mediated by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. |
| Protein Name | Netrin Receptor Unc5aProtein Unc-5 Homolog 1Protein Unc-5 Homolog A |
| Database Links | Reactome: R-HSA-373752Reactome: R-HSA-418886Reactome: R-HSA-418889 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinMembrane RaftCell ProjectionNeuron ProjectionThe Interaction With Prkcabp Regulates Its Surface Expression And Leads To Its Removal From The Surface Of Neurons And Growth Cones |
| Alternative Antibody Names | Anti-Netrin Receptor Unc5a antibodyAnti-Protein Unc-5 Homolog 1 antibodyAnti-Protein Unc-5 Homolog A antibodyAnti-UNC5A antibodyAnti-KIAA1976 antibodyAnti-UNC5H1 antibody |
Information sourced from Uniprot.org