| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Protein unc-119 homolog A (153-203 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
UNC119 |
| Gene ID: |
9094 |
| Uniprot ID: |
U119A_HUMAN |
| Immunogen Region: |
153-203 aa |
| Specificity: |
This antibody detects endogenous levels of U119A at Human/Mouse/Rat |
| Immunogen: |
Synthesized peptide derived from the human U119A at the amino acid range 153-203 |
| Post Translational Modifications | Phosphorylation suppresses its interaction with KLHL18 and down-regulates its KLHL18-mediated degradation. Phosphorylated more under light conditions than dark conditions. Dephosphorylated by calcineurin. |
| Function | Involved in synaptic functions in photoreceptor cells, the signal transduction in immune cells as a Src family kinase activator, endosome recycling, the uptake of bacteria and endocytosis, protein trafficking in sensory neurons and as lipid-binding chaperone with specificity for a diverse subset of myristoylated proteins. Specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Binds myristoylated GNAT1 and is required for G-protein localization and trafficking in sensory neurons. Probably plays a role in trafficking proteins in photoreceptor cells. Plays important roles in mediating Src family kinase signals for the completion of cytokinesis via RAB11A. |
| Protein Name | Protein Unc-119 Homolog ARetinal Protein 4Hrg4 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeSpindle PoleSpindleLocalizes To The Centrosome In Interphase Cells And Begins To Translocate From The Spindle Pole To The Spindle Midzone After The Onset Of MitosisIt Then Localizes To The Intercellular Bridge In Telophase Cells And To The Midbody In Cytokinetic Cells |
| Alternative Antibody Names | Anti-Protein Unc-119 Homolog A antibodyAnti-Retinal Protein 4 antibodyAnti-Hrg4 antibodyAnti-UNC119 antibodyAnti-RG4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
