Host: | Rabbit |
Applications: | WB |
Reactivity: | Human/Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-UIMC1 (449-719) is suitable for use in Western Blot research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
Purification: | Affinity purification |
Dilution Range: | WB 1:500-1:2000 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | UIMC1 |
Gene ID: | 51720 |
Uniprot ID: | UIMC1_HUMAN |
Immunogen Region: | 449-719 |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 449-719 of human UIMC1 (NP_057374.3). |
Immunogen Sequence: | QLSSSETFDLEREVSPGSRD ILDGVRIIMADKEVGNKEDA EKEVAISTFSSSNQVSCPLC DQCFPPTKIERHAMYCNGLM EEDTVLTRRQKEAKTKSDSG TAAQTSLDIDKNEKCYLCKS LVPFREYQCHVDSCLQLAKA DQGDGPEGSGRACSTVEGKW QQRLKNPKEKGHSEGRLLSF LEQSEHKTSDADIKSSETGA FRVPSPGMEEAGCSREMQSS FTRRDLNESPVKSFVSISE |
Tissue Specificity | Expressed in testis, ovary, thymus and heart. Expressed in germ cells of the testis. |
Post Translational Modifications | Sumoylated. Phosphorylated upon DNA damage by ATM or ATR. |
Function | Ubiquitin-binding protein. Specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B.the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1. |
Protein Name | Brca1-A Complex Subunit Rap80 Receptor-Associated Protein 80 Retinoid X Receptor-Interacting Protein 110 Ubiquitin Interaction Motif-Containing Protein 1 |
Database Links | Reactome: R-HSA-5689901 Reactome: R-HSA-5693565 Reactome: R-HSA-5693571 Reactome: R-HSA-5693607 Reactome: R-HSA-69473 |
Cellular Localisation | Nucleus Localizes At Sites Of Dna Damage At Double-Strand Breaks (Dsbs) |
Alternative Antibody Names | Anti-Brca1-A Complex Subunit Rap80 antibody Anti-Receptor-Associated Protein 80 antibody Anti-Retinoid X Receptor-Interacting Protein 110 antibody Anti-Ubiquitin Interaction Motif-Containing Protein 1 antibody Anti-UIMC1 antibody Anti-RAP80 antibody Anti-RXRIP110 antibody |
Information sourced from Uniprot.org