| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-UIMC1 (449-719) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
UIMC1 |
| Gene ID: |
51720 |
| Uniprot ID: |
UIMC1_HUMAN |
| Immunogen Region: |
449-719 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 449-719 of human UIMC1 (NP_057374.3). |
| Immunogen Sequence: |
QLSSSETFDLEREVSPGSRD ILDGVRIIMADKEVGNKEDA EKEVAISTFSSSNQVSCPLC DQCFPPTKIERHAMYCNGLM EEDTVLTRRQKEAKTKSDSG TAAQTSLDIDKNEKCYLCKS LVPFREYQCHVDSCLQLAKA DQGDGPEGSGRACSTVEGKW QQRLKNPKEKGHSEGRLLSF LEQSEHKTSDADIKSSETGA FRVPSPGMEEAGCSREMQSS FTRRDLNESPVKSFVSISE |
| Tissue Specificity | Expressed in testis, ovary, thymus and heart. Expressed in germ cells of the testis. |
| Post Translational Modifications | Sumoylated. Phosphorylated upon DNA damage by ATM or ATR. |
| Function | Ubiquitin-binding protein. Specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B.the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1. |
| Protein Name | Brca1-A Complex Subunit Rap80Receptor-Associated Protein 80Retinoid X Receptor-Interacting Protein 110Ubiquitin Interaction Motif-Containing Protein 1 |
| Database Links | Reactome: R-HSA-5689901Reactome: R-HSA-5693565Reactome: R-HSA-5693571Reactome: R-HSA-5693607Reactome: R-HSA-69473 |
| Cellular Localisation | NucleusLocalizes At Sites Of Dna Damage At Double-Strand Breaks (Dsbs) |
| Alternative Antibody Names | Anti-Brca1-A Complex Subunit Rap80 antibodyAnti-Receptor-Associated Protein 80 antibodyAnti-Retinoid X Receptor-Interacting Protein 110 antibodyAnti-Ubiquitin Interaction Motif-Containing Protein 1 antibodyAnti-UIMC1 antibodyAnti-RAP80 antibodyAnti-RXRIP110 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
